The driving distance is approximately 1,311 road miles (2,109 km) - about 20.5 hours of driving time, depending on your average speed, traffic conditions and the route(s) you take.
The driving distance is 320 miles using I-95 S.
The driving distance is about 71 miles using US-17 S.
The driving distance is about 35 miles on the I-880 S.
According to Yahoo Maps, driving from S. Main Street, Calais ME to Congress Street in Downtown Boston is a trip of just over 330 miles, taking approximately 6 hours.
66 miles on I-95 S and I-295 S.
113 road miles I-805 S and I-5 S.
118 Miles - 191 Km
About 21 miles on the I-405 S.
1,162 road miles on I-75 S.
245 miles on I-95 S.
446 road miles on I-35 S and I-45 S.