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Louisiana, with New Orleans. In fact, it was so important that the US wanted this port. The US offered to buy the land of New Orleans from France, which at the time was a part of the French territory of Louisiana. However, France saw no use for the land of Louisiana any longer and offered the whole territory to the US. The US excepted and this is how the country acquired the Louisiana Territory.

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Q: What state had the most important port on Mississippi river?
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