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Osteoarthritis (also know as "wear-and-tear Arthritis")- Normal joint use prompts the release of metalloproteinase enzymes that break down articular cartilage. In healthy individuals, this cartilage is eventually replaced. In people with OA, more cartilage is destroyed than replaced. OA may reflect the cumulative effects of years of compression and abrasion at joint surfaces, causing excessive amounts of metalloproteinase enzyme release, which results in softened, roughened, pitted, and eroded articular cartilages.

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