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The cell membrane contains P-gp (permeability glycoprotein). If you mean what tissues are mostly involved: intestinal lining, liver cells, kidney tubular cells, adrenal gland cells and the cells comprising the blood-brain and blood-testis barrier. This transporter helps and blocks other substances from entering and leaving cells. Some drugs block it's ability to act as a transporter.

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Q: What structures most likely transport P-gp?
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