Assuming you meant "6th Avenue and 45th Street": the easiest way would be to take the Uptown 1, 2, or 3 trains (the red line) ONE STOP from Penn Station/West 34th Street to Times Square/West 42nd Street.
You will exit the subway at around 7th Avenue and 42nd Street. Walk north 3 blocks to West 45th Street. Then turn right, and walk one block east to 6th Avenue.
The trip lasts about 45 minutes.
45 minutes
Yellow cabs charge a flat rate of $45 (NOT including tolls, tips and tax) for all trips between JFK and Manhattan. Car service companies will charge similar rates. By train, it will cost $7.50: $5 for the AirTrain shuttle from JFK to the Howard Beach subway station (on the A train, of the A-C-E, the blue line), and then $2.50 for a Single Ride subway ticket. The A train stops at 34th Street-Penn Station in Manhattan.
Take the Uptown A or C (of the A-C-E, the blue line) from 34th Street-Penn Station to 59th Street-Columbus Circle. At 59th Street-Columbus Circle, transfer to the Uptown B or D trains. Take the Uptown B or D to 161st Street-Yankee Stadium.The Bronx-bound D train does not stop at Yankee Stadium on weekdays from 4 to 6:45 PM, so if you are traveling during those times, you need to take the B.Don't take the B unless you are traveling on a weekday between 4 and 6:45 PM, because the B only stops at Yankee Stadium when the D isn't stopping there.
There is a $45 flat rate for yellow taxis (NOT including tips and tolls), for all trips between JFK and Manhattan. Car services such as Carmel (212-666-6666) or Dial 7 Car & Limo (212-777-7777) charge similar rates (between $40 and $50, again, NOT including tips and tolls). Yellow cabs carry up to four passengers, and car services likely have the same policy. If you take Super Shuttle (1-800-BLUE-VAN) it will cost $26 for one passenger to go from Penn Station to JFK, and $37 for two passengers. For each additional passenger, the per-passenger charge is cheaper. You can also take the subway, for a total cost of $7.25 ($2.25 for the subway, and $5 for the shuttle, called the AirTrain, to the JFK terminals). Take the Downtown A train from 34th Street-Penn Station to the Howard Beach Station. At the Howard Beach Station, get the AirTrain to the JFK terminals.
Using what method of travel? A car, bus, subway, or walking? On the subway it's about half an hour, not including the time it takes to walk there from the station:Take the Uptown E train (of the A-C-E, the blue line) from 34th Street-Penn Station to 53rd Street-Lexington Avenue. Transfer is available between the 53rd Street-Lexington Avenue Station on the E train and the 51st Street Station on the 6 train (of the 4-5-6, the dark green line). Take the Uptown 6 to 77th Street (at Lexington Avenue). Then walk 3 blocks north and 4 1/2 blocks east to 510 East 80th Street between York and East End Avenues.In a car, it really depends on traffic. Somewhere between 20 minutes and an hour.On a bus, it's like 45 minutes to an hour.Walking, it's about an hour and a half.
It depends on where in the Bronx you're coming from, and where in Manhattan you're going. The shortest travel time would be 5 minutes, if you're coming from the southernmost station in the Bronx, and going to the northernmost station in Manhattan. The longest travel time would be an hour and a half or an hour and forty minutes, if you're coming from 241st Street and going to Lower Manhattan. So the average travel time would be about 45 minutes.
About 45 minutes.
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Currently, the Lake Shore Limited leaves Cleveland at 5:50 am and arives in New York's Penn Station at 6:35 pm. The returning train leaves New York at 3:45 pm and arrives in Cleveland at 3:27 am.
Oxford St is 0.75 Miles
About 45 minutes.