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Assuming you meant "6th Avenue and 45th Street": the easiest way would be to take the Uptown 1, 2, or 3 trains (the red line) ONE STOP from Penn Station/West 34th Street to Times Square/West 42nd Street.

You will exit the subway at around 7th Avenue and 42nd Street. Walk north 3 blocks to West 45th Street. Then turn right, and walk one block east to 6th Avenue.

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Q: What subway do you take from Penn Station to get to 6 and 45?
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