The answer, interestingly enough, is NOT Middletown. Middletown is closer to Dayton than it is to Cincinnati. The closest city center to be at the halfway point is Monroe, Ohio. Downtown Monroe is just over 24 miles from downtown Cincinnati as the crow flies (30½ miles by road), and just under 24 miles as the crow flies (27.1 miles by road) from downtown Dayton.
Caldwell, WV is the halfway point. It is close to the George Washington National Forest.
Middleton
The halfway point between Medina and Dayton is on I-71 just north of Columbus, near Sunbury, Delaware, and Alum Creek State Park.
Dayton Ohio
Cincinnati is he halfway point between Dayton Ohio and Lexington Kentucky. There are 135.61 miles between the two.
theres nothing really there dont refer to it as a city
Indiana
Halfway between Columbus and Cincinnati
Princeton, KY
Altoona, Pennsylvania is halfway between Hartford and Columbus
There is approximately 2,327 miles between these two cities. Halfway would be 1,164 miles, in the Badlands of South Dakota, near Scenic, SD.
Hotchkiss, VA.
Defiance, Ohio is the approximate halfway point.
It is 71.7 miles according to Google Maps.