Chicago and Los Angeles
Route 66
the silk route is a route to china.
The two cities that route 66 runs through are Chicago and L.A.
The First Crusades traveled east and conquered 3/5 cities in Eurasia. Two cities in Europe were not conquered, and three cities in the Asia Minor were conquered. They traveled through the Holy Roman Empire and Byzantine Empire.
US-67 would be the road that goes through both towns, meaning that this roadway connects both Arkadelphia, Arkansas and Texarkana, Arkansas. Another route that could be considered to connect the two cities is Interstate 30, which does not run through Arkadelphia but serves as a quicker route between the two cities.
Damascus
First scheduled London-Paris passenger service (using airplanes). Aircraft Travel and Transport inaugurated London-Paris service (Aug. 25). Later the company started the first trans-Channel mail service on the same route (Nov. 10).
They noticed cities full of dead people. black death caused cities near trade route to suffer greatly.
You and your bags will need to go through customs once. After this you will be kept separate from the non international passengers. Some airports can not perform this function so the customs will occur enroute. Normally this will happen at the first international flight.
Los Angeles and Chicago
because its a vital transportation route. Canals connect it and other rivers of European Russia.