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Glucose and fructose are two structural isomers: they both have the formula C6H12O6, but differ in the arrangement of those atoms within their molecules. Glucose forms a ring with six carbons, while fructose forms rings with only five carbons (the rest are attached to the outside of the ring.) These different structures give the two different properties and make them react differently.

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Q: What two sugars are structural isomer and what makes them different?
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Is regioisomer a synonym of stereoisomer?

I don't think so... A stereoisomer is definitely an isomer which is related to another molecule by the orientation of its atoms in space rather than its connectivity. In other words, if you have a chiral molecule, with a stereocenter, that molecule can exist as multiple stereoisomers.I couldn't find much on regioisomer, but "regioselectivity" generally refers to the preference of one direction of http://www.answers.com/ making or breaking over all other possible directions. In other words, when adding a molecule, such as HX, where X is a halide, across a double bond, the regioselectivity refers to the preference for adding the H to one side of the bond and the X to the other.See the Web Links to the left of this answer for some more information. From what I can gather regioisomer is rather more synonymous with structural/constitutional isomer, where the atoms differ in their connectivity. E.g. ethanol and dimethylether, which both have the molecular formula C2H6O but have different arrangements of their atoms (CH3-CH2-OH and CH3-O-CH3 respectively). I can't find a clear definition of regioisomer anywhere, which makes me wonder if there's more to it, but the online dictionaries and encyclopedias I've looked at all refer me to structural isomers when I search for it. Also, my textbook lists various 'regiospecific' and 'regioselective' reactions, where the product is one of a number of possible STRUCTURAL isomers. This contrasts to the stereospecific and stereoselective reactions given, where the product is one of a number of potential stereoisomers, i.e. molecules that have the SAME atom connectivity but different 3D arrangements in space. So I'd use regioiomer as another term for structural/constitutional isomer, not stereoisomer.