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Lead intoxication affects many systems of the body including the cardiovascular, renal, and reproductive systems. Its most detrimental effects occur in the nervous system, where lead blocks the receptor know as N-methyl-D-aspartate, an effective receptor involved in the maturation of brain plasticity.
The toxicity of lead plays a major role in the communication between astrocytes and endothelial cells.By disrupting the blood-brain barrier, it causes encephalopathy and edema that primarily affects the cerebellum.
Intracellularly, lead replaces calcium as a second messenger, binding with calmodulin more readily than calcium, resulting in an alteration in protein conformation.

Intracellularly, lead replaces calcium as a second messenger, binding with calmodulin more readily than calcium, resulting in an alteration in protein conformation.

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9y ago

Lead intoxication affects many systems of the body including the cardiovascular, renal, and reproductive systems. Its most detrimental effects occur in the nervous system, where lead blocks the receptor know as N-methyl-D-aspartate, an effective receptor involved in the maturation of brain plasticity.
The toxicity of lead plays a major role in the communication between astrocytes and endothelial cells.By disrupting the blood-brain barrier, it causes encephalopathy and edema that primarily affects the cerebellum.
Intracellularly, lead replaces calcium as a second messenger, binding with calmodulin more readily than calcium, resulting in an alteration in protein conformation.

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9y ago

Intracellularly, lead replaces calcium as a second messenger, binding with calmodulin more readily than calcium, resulting in an alteration in protein conformation.

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Q: What type of chemicals in your body does soluble salts of lead destroy?
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