I'm not sure what you mean by "significance" in this case.
Jethro is one of the names given to Moses' father-in-law, and he's said to be a priest (the word could be translated as prince, though priest makes more sense) of Midian. (Moses' father-in-law is sometimes called Reuel or Hobab. It's not absolutely clear whether he had several names (such as Abram/Abraham or Jacob/Israel), or whether some of these are actually titles rather than names.)
He appears to have at one time been an idolator who converted to worship of YHVH.
Moses got water for the sheep of Jethro, as his daughters were looking after them. He then married one of Jethro daughters.
Jethro Lazenby goes by Jethro Cave.
Jethro Cave's birth name is Jethro Leroy Ingmar Lazenby.
To take jethro to teach him.
Jethro Dionisio was born in 1972.
Jethro Compton was born in 1988.
Jethro Robinson was born in 1914.
Jethro Teall died in 1924.
Jethro Teall was born in 1849.
Jethro Sumner died in 1785.
Jethro Cave is 6' 1".
Jethro Sumner was born in 1733.