What was the most dangerous experience to the wives of the colonies?

Up until the early 1900s, childbirth had always been the most dangerous experience for women. Many women and/or their infants died during childbirth. Or, women would get a uterine infection after delivery---there were no antibiotics back then, so the women died. Considering that women typically had large families of 5 to 15 children and with pregnancies 12 to 18 months apart--and even more pregnancies if we add in miscarriages or stillbirths--the childbirth risk was huge and widespread.