What was the most dangerous experience to the wives of the colonies?

Indian
Up until the early 1900s, childbirth had always been the most dangerous experience for women. Many women and/or their infants died during childbirth. Or, women would get a uterine infection after delivery---there were no antibiotics back then, so the women died. Considering that women typically had large families of 5 to 15 children and with pregnancies 12 to 18 months apart--and even more pregnancies if we add in miscarriages or stillbirths--the childbirth risk was huge and widespread.