You need to specify what the changes were a result of if you make it possible to answer your question. There were many changes in ancient Rome over the 1,200 years of her history and they were the result of many different things.
If the changes seen under the microscope don't point to any particular diagnosis, the biopsy result will be nonspecific.
Athena was last seen in Rome
the rome captive the jews
civil war
It destroyed the walls
Physical change, if it changes in a way to be seen, or chemical change, which if the change can not be seen
Sistine Chapel in The Vatican.
Most chemical changes happen between molecules, so they are unseen.
Rome won
Rome.
what changes happened at the time as a result of this scientists work
augustus changed it by being smart and ending war