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He died of a fever. It is unknown whether this was a natural event or whether it was induced by poisoning.

His empire was divided up by this generals, who fought over the spoils. It eventually settled down to the separate kingdoms (we call them today the Hellenistic kingdoms) of Macedonia, Egypt, Syria-Mesopotamia and Pergamon, which were subsequently incorporated into the expanding Roman Empire.

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Q: What were the major causes and consequences of Alexanders death?
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