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Nothing different than taking it with the capsule. It is just there to hold the beads in. The actual amphetamine is inside the little beads. There are 2 different kinds of beads. One dissolves within half an hour and the other dissolves 4 hours later. This is what makes it time release. That is why they say do not crush on the bottle. If you crush them, you eliminate the time release.

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Q: What will happen if you take an opened time release Adderall capsule?
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