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You should monitor the renal functions because amphotericin B is known to cause nephrotoxicity (lower incidence with lipid formulations). The patient's glomerular will show an increased BUN (Blood Urea Nitrogen) and increased serum creatinine; the tubular will show K+ (potassium ion) and/or Mg2+ (magnesium ion) wasting. To manage the patient's condition better, 0.5-1 L normal saline should be given 30-60 min prior to every dose of amphotericin B, and electrolytes should be supplemented. Other things to watch out are phlebitis, anemia, lipid formulations may cause a pulmonary reaction, and liposomal formulations may cause hyperbilirubinemia. In addition, look out for drug interactions which include other nephrotoxins (e.g. aminoglycosides, vancomycin, cyclosporine). Amphotericin are also incompatible with many IV solutions since they have the risk of precipitation.

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Q: What will you monitor in patient taking amphotericin B?
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