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There are many things such as defective high tension wires, defective cap and/or rotor, old or fouled or poorly adjusted plugs. Also take a look at the #7 and 8 spark plug wire routings. They should NOT be beside one another, they must have wires 5 and 6 between them from the distributor up to the holder atop the valve cover. As they fire consecutively one sometimes tends to also fire the other. This is clearly indicated in any Ford manual for this ignition system.

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Q: What would cause a Ford 5.0 engine to misfire?
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