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What would the effect on translation be of a single base pair deletion in an organism's DNA?
Wiki User
∙ 13y ago
Assuming that the deletion occurs somewhere in the protein coding region of an organism's DNA - that is any where within it's Genome excluding introns and other non-expressed regions - :
mRNA sequence (transcribed from DNA) is translated into protein using triplet - codons, meaning that three consecutive nucleotide bases code for one amino acid (a building block of the protein chain). For example:
UUU CCU CAA A.... (nucleotides) codes for
Phe Pro Asn ... (3 letter abbr. for amino acids). Now, if the first nucleotide gets deleted, we get:
UUC CUC AAA that translates into:
Phe Leu Lys .
What happens is that triplets shift to the right by one nucleotide and that changes the meaning of all triplets that follow resulting in a protein with a different amino acid composition [sequence] that almost for certain has lost its intended function or even becomes damaging to the organism - these are rarely beneficial due to the following: these are called Frame-Shift mutations and you are quite right they usually have quite a deleterious effect.
Wiki User
∙ 13y ago
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A involves the addition or deletion of a single base in a DNA molecule.?
A Frameshift mutation
Which mutation results in a single missing letter in the genetic code?
frameshift mutation: deletion
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Bacteria are single celled organisms?
yes bacteria is a single celled organisms.
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Do all organisms begin as a single cell-?
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Is bacteria single or multicellular?
Usually Bacteria is unicellular, but in some cases multicellular.
