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Isabella Medici was born in 1542 and died in 1576. She never held the title of Duchess of Florence (Tuscany). She was the daughter of Cosimo I, Duke of Tuscany and the sister of Francesco I who succeded his father as Duke in 1574. She married Paolo Giordano Orsini in 1558. In 1560 Pope Pius IV named Orsini the Duke of Bracciano and Isabella, his wife, became the Duchess of Bracciano.

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