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Although HIV-1 and HIV-2 are closely related, they are thought to have jumped from primates to humans at different times (and from different species).

HIV-1 is by far the more virulent of the two species of HIV.

Because HIV-1 is more easily transmitted, it also spreads more readily and therefore accounts for the vast majority of global HIV infections.

HIV-2, because it is much less transmittable, is largely confined to West Africa (where it is thought to have originated) and to West African migrant communities in Europe.

HIV-1 also mutates more efficiently that HIV-2 and generally progesses to AIDS at a significantly faster rate than HIV-2 does.

Also, HIV-2 has Vpr and Vpx proteins. HIV-1 has only Vpr. Differences between these proteins are actually on research.

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Linnea Beatty

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3y ago

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