Although HIV-1 and HIV-2 are closely related, they are thought to have jumped from primates to humans at different times (and from different species).
HIV-1 is by far the more virulent of the two species of HIV.
Because HIV-1 is more easily transmitted, it also spreads more readily and therefore accounts for the vast majority of global HIV infections.
HIV-2, because it is much less transmittable, is largely confined to West Africa (where it is thought to have originated) and to West African migrant communities in Europe.
HIV-1 also mutates more efficiently that HIV-2 and generally progesses to AIDS at a significantly faster rate than HIV-2 does.
Also, HIV-2 has Vpr and Vpx proteins. HIV-1 has only Vpr. Differences between these proteins are actually on research.
Both HIV-1 and HIV-2 are equally "dangerous" in that both are sexually transmitted and both lead to AIDS. There are several difference between the two, in terms of how transmissible they are and how each progressess. The bottom line--you want to avoid either type of the virus.
HIV 1 can cause fever, headache, fatigue, swollen lymph glands, and a rash. HIV 2 can cause all of those plus confusion, diarrhea, mouth sores, stiff muscles, forgetfulness, and night sweats.
Because no whole cells of HIV have ever been isolated from human tissues. In theory, a retrovirus known as HIV1 and its variant HIV2 cause Acquired Immune Deficiency Syndrome, but as yet, it has not been isolated as a whole cell. A culture can only start with actual cells, not theoretical ones.
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