When and how did Christopher Columbus die?

On May 20, 1506, at about the age of 55, Columbus died in Valladolid, fairly wealthy from the gold his men had accumulated in Hispaniola. He died of an unknown illness. According to his personal diaries and notes by contemporaries, the symptoms of this illness (burning pain during urination, pain and swelling of the knees, and conjunctivitis of the eyes) were clearly visible in his last three years link for more info http://en.wikipedia.org/wiki/Christopher_Columbus