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If you mean shortly after the doe has given birth, she'll take care of the cleaning.

Once she allows the babies out to run around - and it's her decision - then it becomes important for you to handle them daily.

This gives you a double opportunity: you can remove the doe to a separate area and clean the nesting box and the rest of the cage, while taking the time to let the little ones crawl over your hands and begin to get an idea of humans. Don't hold them at this stage.

Watch them all carefully when you put them back together and make sure fresh water is available as well as some kind of treat, so they feel rewarded for being separated and now back together.

Sunflower seeds are good, scattered about for them to discover, but you know your own mice best and will have a good idea of what they reckon is a treat. One of those round ice cream cones is good because they all forget any worries they might've had and play in and over and around it, and chew at it. Otherwise, anything they can all hold in their paws to nibble on, which is comforting for Mum and a learning experience for her family.

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Q: When can you clean a mouse nest?
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