Want this question answered?
Acetylcholine
The neurotransmitter acetylcholine is released into the synaptic cleft to bind with receptors on muscle cells. Upon binding, the muscle cells contract.
synaptic cleft
The NMJ is the region where the efferent motor nerves connect with muscle tissue. When a signal is sent from the brain, down the spinal cord, to the nerve, neurotransmitters are released into the synaptic cleft (primary acetylcholine), which cause the muscle to contract.
When you decide to move, an electrical signal called an action potential is generated in your brain. This signal travels along your neurons and reaches the skeletal muscle cells via motor neurons. At the neuromuscular junction, a chemical called acetylcholine is released, which stimulates the muscle fibers to contract and initiate movement.
acetylcholine
A, acetylcholine. Acetylcholine is commonly secreted at neuromuscular junctions, the gaps between motor neurons and muscle cells, where it stimulates muscules to contract. At other kinds of junctions, it typically produces and inhibitory post-synaptic potential.
acetylcholine
Parasympathetic system has acetylcholine as its chemical mediator.
The synaptic knob contains vesicles filled with neurotransmitters. Therefore, Acetylcholine is the neurotransmitter that stimulates skeletal muscle to contract. It is released into the synaptic clefts between motor neuron axons and motor end plates.
A signal is generated in the motor cortex of the brain, and travels down the spinal cord to the affected motor neurons. As the action potential travels down the axon of the final motor neuron, it causes calcium influx and exocytosis of acetylcholine-containing vesicles, releasing acetylcholine into the neuromuscular junction. From there, acetylcholine binds with receptors on the muscle fiber end plates, where it depolarizes the muscle fiber, causing contraction of the muscle.
Acetylcholine is the neurotransmitter at the neuromuscular junction.