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For centuries, South American natives like the Incas had been chewing the leaves of the coca plant, to stave off hunger, and to keep them energized on long journeys. The Spanish conquistadors brought coca back to the Old World with them, and in 1859, scientists managed to isolate the active ingredient in the coca plant, and make it into liquid or powder cocaine.

So, 1859 would be the answer (since the Incas were not using powder or liquid cocaine, but only chewing the leaves of the plant it comes from).

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Q: When was cocaine first used?
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