If you mean just two major cities in Europe, and two major cities in Asia, here are examples: Europe - Moscow & London Asia- Shanghai & Tokyo If you mean two cities that span the continents of Europe and Asia, two examples are Istanbul & Orenburg.
Paris and Rome
The answer to what differs London with Europe is there two different cities and all that
Paris and Madrid
u and ur mama
Amsterdam, Athens, Andorra la Vella
Amsterdam, Athens, Andorra la Vella
New York and Florida and Europe and Asia and Austalia
Genoa and Venice are the two cities I would pick to answer this. In their time they were by far the most important European trading cities for Asian goods. There were other cities that were very important at other times, however, including Constantinople.
Hungary
London, located on the Thames River, and Paris located on the Seine River
Istanbul is the Turkish city located on two continents. It is located in Europe and Asia, separated by the Bosporus.