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The polypeptide chain of hemoglobin that is designated beta and that when deficient or defective causes various anemias?
The polypeptide chain of hemoglobin designated beta is encoded by the HBB gene. Mutations in this gene can lead to conditions such as sickle cell anemia and beta thalassemia, causing a range of symptoms including anemia, fatigue, and complications related to reduced oxygen transport in the blood. Treatment options for these conditions include blood transfusions, medications, and in some cases, bone marrow transplant.
What is alfa-thalassamie?
Anemia These drugs include epoetin Alfa (Procrit, Epogen, and Eprex) and darbepoetin Alfa (Aranesp).... The two major forms are thalassemia minor and thalassemia major (Cooley's anemia, beta thalassemia).....What Is Thalassemia?(also known as Mediterranean anemia, or Cooley's Anemia) is a genetic blood disease. People born with this disease cannot make normal hemoglobin (anemia) which is needed to produce healthy red blood cells.Who carries Thalassemia?People of Chinese, South Asian, Middle Eastern, Mediterranean or African origin.What is Thalassemia Minor?People with a thalassemia mutation only in one gene are known as carriers or are said to have thalassemia minor. Thalassemia minor results in no anemia or very slight anemia. People who are carriers do not require blood transfusion or iron therapy, unless proven to be iron deficient.What is Thalassemia Major?Children born with thalassemia major usually develop the symptons of severe anemia within the first year of life. Lacking the ability to produce normal adult hemoglobin, children with thalassemia major:- are chronically fatiqued- fail to thrive, and- do not grow normallyProlonged anemia will cause bone deformities and eventually will lead to death within the first decade of life. The only treatment to combat severe anemia is regular blood transfusions.How can Thalassemia be treated?Regular blood transfusions allow patients with thalassemia major to grow normally and be active. Unfortunately, transfusions result in deadly accumulation of iron in the hearts and livers of patients by their teenage years. If the excess iron is not removed then the patients may suffer from a premature death due to iron overload.Nowadays, drugs designed to remove excess iron (iron chelators) have significantly changed the prognosis of thalassemia major. Patients can grow and develop normally, with relatively normal heart and liver functions. Adult patients are living into their forties and some have children of their own.Despite improved prognosis, many patients find the nightly 10 hour infusions difficult or painful and are reluctant to comply with their doctor's orders. These patients are not free of risk and may die prematurely due to iron overload.Current treatments allow thalassemia patients to live relatively normal lives, however, a cure remains to be found. The genetic cause of thalassemia was one of the first genes discovered in the 1970's, yet 30 years later, gene therapy still eludes thalassemia patients.Do you carry Thalassemia?Many people from the areas of the world where thalassemia is common carry the gene for it on one chromosome (that is, they have thalassemia minor). You may believe that your blood has been tested for this specific gene but testing for thalassemia requires a special blood test. To be tested your doctor must order a blood test called HEMOGLOBIN ELECTROPHORESIS which can identify a carrier of thalassemia.If you, your parents or ancestors are from an area of the world where thalassemia is common, PLEASE REQUEST hemoglobin electrophoresis blood test from your doctor.It is important to identify yourself as a possible carrier of thalassemia (thalassemia minor). A person with thalassemia minor has a 25%(1 in 4) chance of having a baby with THALASSEMIA MAJOR if his/her mate also has thalassemia minor. http://www.thalassemia.ca/viewarticle.asp?aID=31&searchQ=F.A.Q
What are the disadvantages of using Windows 7 beta?
It's beta, it means that it has some glitches (it can be ustable too) and most likely it will be hard to find drivers for it.
What is thalasimia?
Thalassemia is a genetic blood disorder characterized by the reduced production of hemoglobin, the protein in red blood cells responsible for carrying oxygen. This condition leads to anemia, which can cause fatigue, weakness, and other health complications. There are two main types: alpha and beta thalassemia, depending on which part of the hemoglobin molecule is affected. Treatment options may include blood transfusions, iron chelation therapy, and, in some cases, bone marrow transplantation.
What is hgb hic?
HGB HIC, or Hemoglobin H Disease, is a type of thalassemia, specifically an alpha-thalassemia disorder. It occurs when there is a deficiency in the production of alpha globin chains, leading to an excess of beta globin chains that form unstable hemoglobin (Hemoglobin H). This condition can result in moderate to severe anemia, fatigue, and other health complications. Management typically involves regular monitoring and supportive care, and in some cases, blood transfusions may be necessary.
Can some 1 tell you what sites to go to so you easily download the wotlk beta so you can play?
You can't play Wotlk Beta retail, but you can search in Internet and download wotlk beta . Plus if you get lucky you would find a beta private server to play on.
Can kulekhara cure thalassemia?
Kulekhara, also known as "Kulekhara leaf" or "Kulekhara herb," is traditionally used in some cultures for various health benefits, but there is no scientific evidence to support its effectiveness in curing thalassemia. Thalassemia is a genetic blood disorder that affects hemoglobin production, and its management typically involves blood transfusions, iron chelation therapy, and other medical interventions. It's crucial for individuals with thalassemia to consult healthcare professionals for appropriate treatment rather than relying on herbal remedies.
Where can one find more information about CHDK?
To find out more information about CHDK, it is advised to surf the web or do some research to find out what it is or where to find out more information about it.
How do you find the length of the arc if r equals 9.234 mm beta equals 5 pi over 4?
It depends on which angle beta is: the angle subtended by the arc at the centre of the circle (assuming that it is a circle and not an ellipse or some other shape), otr the angle subtended by the chord and one of the radii. Basically, there is not enough information provided in the question to give a sensible answer.
Where can I find more information on caring for aging parents?
You can find some direct information from hospitals and some clinics in or near your town. Rehab centers have some information on the too. So check them out.
Where can I find online information about centric brakes?
You can find some online information about centric brakes from some automobile discussion forums and automotive sales blogs that will have some information about different types.
Thalassemia?
DefinitionThalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of hemoglobin, the protein in red blood cells that carries oxygen. The disorder results in excessive destruction of red blood cells, which leads to anemia.See also:Hemolytic anemiaSickle cell diseaseAlternative NamesMediterranean anemia; Cooley's anemia; Beta thalassemia; Alpha thalassemiaCauses, incidence, and risk factorsHemoglobin is made of two proteins: Alpha globin and beta globin. Thalassemia occurs when there is a defect in a gene that helps control production of one of these proteins.There are two main types of thalassemia:Alpha thalassemia occurs when a gene or genes related to the alpha globin protein are missing or changed (mutated).Beta thalassemia occurs when similar gene defects affect production of the beta globin protein.Alpha thalassemias occur most commonly in persons from southeast Asia, the Middle East, China, and in those of African descent.Beta thalassemias occur in persons of Mediterranean origin, and to a lesser extent, Chinese, other Asians, and African Americans.There are many forms of thalassemia. Each type has many different subtypes. Both alpha and beta thalassemia include the following two forms:Thalassemia majorThalassemia minorYou must inherit the defective gene from both parents to develop thalassemia major.Thalassemia minor occurs if you receive the defective gene from only one parent. Persons with this form of the disorder are carriers of the disease and usually do not have symptoms.Beta thalassemia major is also called Cooley's anemia.Risk factors for thalassemia include:Asian, Chinese, Mediterranean, or African American ethnicityFamily history of the disorderSymptomsThe most severe form of alpha thalassemia major causes stillbirth (death of the unborn baby during birth or the late stages of pregnancy).Children born with thalessemia major (Cooley's anemia) are normal at birth, but develop severe anemia during the first year of life.Other symptoms can include:Bone deformities in the faceFatigueGrowth failureShortness of breathYellow skin (jaundice)Persons with the minor form of alpha and beta thalassemia have small red blood cells (which are identified by looking at their red blood cells under a microscope), but no symptoms.Signs and testsA physical exam may reveal a swollen (enlarged) spleen.A blood sample will be taken and sent to a laboratory for examination.Red blood cells will appear small and abnormally shaped when looked at under a microscope.A complete blood count (CBC) reveals anemia.A test called hemoglobin electrophoresisshows the presence of an abnormal form of hemoglobin.A test called mutational analysis can help detect alpha thalassemia that cannot be seen with hemoglobin electrophoresis.TreatmentTreatment for thalassemia major often involves regular blood transfusions and folate supplements.If you receive blood transfusions, you should not take iron supplements. Doing so can cause a high amount of iron to build up in the body, which can be harmful.Persons who receive significant numbers of blood transfusions need a treatment called chelation therapy to remove excess iron from the body.Bone marrow transplant may help treat the disease in some patients, especially children.Expectations (prognosis)Severe thalassemia can cause early death due to heart failure a, usually between ages 20 and 30. Frequent blood transfusions with therapy to remove iron from the body helps improve the outcome.Less severe forms of thalassemia usually do not result in a shorter life span.ComplicationsUntreated, thalassemia major leads to heart failure and liver problems, and makes a person more likely to develop infections.Blood transfusions can help control some symptoms, but may result in too much iron which can damage the heart, liver, and endocrine system.Calling your health care providerCall for an appointment with your health care provider if:You or your child has symptoms of thalassemiaYou are being treated for the disorder and new symptoms developPreventionGenetic counseling and prenatal screening may be available to those with a family history of this condition who are planning to have children.ReferencesGiardina PJ, Forget BG. Thalassemia syndromes. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 41.DeBaun MR, Vichinsky E. Hemoglobinopathies. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 462.
