Where did Columbus sail from to America?

On his first voyage he set sail fromPalos in Southern Spain on August 3, 1492, on his second voyage he set sail from Hierro in the Canary Islands on October 13, 1493. On his third voyage he set sail from Sanlucar in Southern Spain on May 30, 1498. Then on his fourth and final voyage he set sail from Cadiz on May 11, 1502. SPAIN SPAIN He didn't set sail from Spain every time, on his Second Voyage he set sail from the Canary Islands, they may have been in the control of Spain at the time, it is still not technically Spain.