Florida's Turnpike/Ronald Reagan Turnpike and FL - 528.
255 miles taking I-4 to Florida's TURNPIKE (toll), then the TURNPIKE SOUTH to Miami.
If you take the Turnpike it's around 300 miles. To get to the TURNPIKE, take SR-44 EAST.
185 miles taking this route:Take Florida's TURNPIKE (toll) SOUTH, from Ft. Lauderdale, to U.S. 1 SOUTH to KEY WEST at END Florida's TURNPIKE in Homestead.Take U.S. 1 SOUTH to Key West.
220 miles taking this route:Take Florida's TURNPIKE (toll) SOUTH, from Boynton Beach, to U.S. 1 SOUTH to KEY WEST at END Florida's TURNPIKE in Homestead.Take U.S. 1 SOUTH to Key West.
223 miles taking this route:Take FLORIDA'S TURNPIKE (toll) NORTH from Palm Beach Gardens to I-75 NORTH at END Florida's Turnpike, north of Orlando.Take I-75 NORTH to Ocala.
150 miles up the TURNPIKE NORTH.
299 miles taking this route:Take I-75 SOUTH from Ft. Myers to Florida's TURNPIKE (toll) SOUTH to KEY WEST at EXIT 5, outside of Miami.Take Florida's Turnpike (toll) SOUTH to U.S. 1 SOUTH to KEY WEST at END Florida's Turnpike in HOMESTEAD.Take U.S. 1 SOUTH to Key West.
The total driving distance from Fort Myers, FL to Key West, FL is 302 miles.Take I-75 SOUTH (towards NAPLES) from Ft Myers to Florida's TURNPIKE (toll) - SOUTH to KEY WEST at EXIT 5. Please note that I-75 thru the Everglades (past Naples) is ALLIGATOR ALLEY, which is a toll road.Take the TURNPIKE (toll) - SOUTH to U.S. 1 SOUTH to HOMESTEAD (and KEY WEST) at the END of the Turnpike in Homestead.Take U.S. 1 SOUTH to Key West.
200 miles taking Florida's TURNPIKE (toll).
194 miles taking Florida's TURNPIKE (toll) NORTH.
34 miles up I-95 or the TURNPIKE NORTH.