For MOTORIZED aircraft, that occurred at KITY HAWK NC USA on December 17, 1903.
1983
Kitty Hawk was the location for the first manned flight, by the Wright Brothers.
On May 5 1961 Mercury 3 took Alan Shepard to space making it America's first manned space flight
The first manned space mission was performed by Yuri Gagarin, a Russian cosmonaut. The mission was called Vostok 1 and it took place April 12, 1961.
There were multiple launches of the Apollo program.The first test flight of the Apollo/SaturnIV spacecraft (AS-201) was unmanned and took place Feb 26, 1966. The first manned flight (Apollo 7) took place Oct 11, 1968. The first moon landing mission (Apollo 11) launched July 16, 1969.
The first manned moon landing took place on 20 July 1969
In 1907 the first known manned helicopter flight took place in France. Paul Cornu built the experimental helicopter and it was reported to have "hopped" approximately 2m up and hovered for less than a minute. http://en.wikipedia.org/wiki/Cornu_helicopter
He was one of the persons who took part in the first free manned ballon flight on the 21st November 1783.
1903
Kittyhawk beach, North Carolina.
It took place at Kittyhawk Beach, North Carolina.
Orville and Wilbur Wright took their first flight in the Wright Flyer, sometimes called the 1903 Flyer. The reason for this was their first flight took place December 17,1903.