Ottawa in Canada is North of Panama. Thereflore the direction of travel is south. Panama City is in Panama, Central America.
You would be going SOUTHEAST. Panama is SE of Yucatan, Mexico.
You would transit the Panama Canal going South.
south
Southeast.
northeast
you would have to travel northwest.
south
You would be going south.
You would be going Southeast.
Egypt and iItily
south
It would be logical; that you would be going North.