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There is little ballistic difference between the two. The .243 will drop about one inch more at 300yards (between 10 and 11 inches) than the 25-06. However the .243 will have a 10 grain advantage in bullet weight. If you are hunting anything bigger than a prairie dog you might want to go with the .243. Otherwise for general varmiting and target shooting the 25-06 will give you an extremely tiny edge.

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Q: Which is better rifle .243 or 25-06 for 300 yd shot?
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