1) Take US-281 NORTH to San Antonio via I-37.
It is 725 miles and the fastest route takes you through Arkansas.
It is 1,723.15 miles via MapQuest's fastest route.
It is 1,098.31 miles via I-10 and I-17 which is MapQuest's fastest route.
Take I-10 WEST to San Antonio.
Google Maps estimates the driving time as 3 hours using I-37.
There aren't many ways to get from San Antonio to Reno, the fastest way would definitely be to take a flight However the fastest way to drive would be to take the Interstate 10 West.
It is 1,203.87 miles via the fastest available driving route according to MapQuest.
The Johnson's Trail(It also went from abline to san antonio)
The drive is around 150 miles, but it's difficult to pin down exactly--there is really no direct route because the Bryan-College Station area isn't on any major highways. The fastest route might involve going out of the way to hit an interstate, plus the heavy traffic in some areas (like around Austin and San Antonio) should be taken into consideration.
About 1,227 miles on the most direct route
Follow U.S. 87 NORTH to Lubbock.