It depends if you want to go through the national park or not. I75 NB to Chatanooga, then cut over through Marysville to Gatlinburg.
Take I-10 WEST to I-75 SOUTH to TAMPA at EXIT 296A.Take I-75 SOUTH to Naples.
If you take a car, according to maps.google.com, the quickest route will be 286 miles and take approximately 4 hours and 21 minutes to drive.
305 miles taking this route: Take I-40 WEST, from Durham, to FOOTHILL PARKWAY to GATLINBURG at EXIT 443.Take FOOTHILL PARKWAY to U.S. 321 SOUTH to GATLINBURG.Take U.S. 321 SOUTH to Gatlinburg.
9 hours northern route and 10 hours southern route
The Gandy Bridge takes you directly from Tampa to St. Petersburg.
I-65 SOUTH (from INDIANA).
Take the Trans-Canada Highway EAST to Montreal.
I am travelling from Bangor Maine to Tampa Florida and I want to bypass New York Ciity. What route should I take?
Take I-95 SOUTH to I-4 WEST.Take I-4 WEST to Tampa.
take the shortest root.
Google Earth cites six or seven hours... depending on which route you take.
Take the turnpike north to Exit 193. Take 60 to 35 to 570 I-4 takes you into Tampa.