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Any OTC medications that contain antihistamines such as Benadryl (diphenhydramine) or chlorpheniramine will cause drowsiness. Even over OTC Zyrtec and Claritin can impair driving abilities especially if mixed with minute quantities of alcohol or other medications like Xanax or Ativan. Some cough and cold remedies usually contain an antihistamine as well. Definitely all the sleep aids will impair driving abilities and impair judgment.

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