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Which two levels of protein structure principally determine the active site of an enzyme?
Wiki User
∙ 10y ago
Quaternary and Tertiary levels of protein structure principally determine the active site of an enzyme.
Wiki User
∙ 10y ago
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Chemical structure of hemoerythrin?
Active site of hemerythrin before and after oxygenation. Single oxygenated hemerythrin protein.
How is Protein Structure related to its function?
The structure of its active site relates to its function, since they have a certain degree of especificity towards substrates.
Does the shape of an enzyme protein determine specificity?
Shape of an enzyme specifically shape of its active site determines enzyme specificity .
How is protein structure involved in enzyme specificity?
The R groups of the amino acids in its active site
Why is protein conformation important?
A protein's shape is very important for its function. For example, enzymes react with substrates at an active site. This is very specific and if the shape changes, it will not react at efficiently (or at all).
Is insulin a tertiary protein structure?
The active form of insulin, in the body, is a tertiary protein structure. However, when stored in the body, several insulin molecules are bound together in a hexamer (a six-protein quaternary structure).
Give an example of the relationship between structure and function?
One example of the relationship between structure and function is found in enzymes as their function is dependent upon its structure. Enzymes are catalytic proteins that speed up a reaction without being consumed. Their protein structure enables them to recognize their substrates, even among isomers, thus allowing them to catalyze very specific reactions. The interactions between a protein's primary structure, its amino acid sequence, determine its secondary structure of hydrogen bonded alpha and beta pleated sheets. The side chains of the amino acids help determine the next superimposed structure, the tertiary structure and the quaternary structure if the protein has one. A protein's conformation enables it to form an active site whose shape is compatible with that of the substrate. Once the substrate enters the active site, the enzyme's structure is altered as induced fit moves the active site's chemical groups into positions that enhance their ability to catalyze the chemical reaction, thus improving the enzyme's function. An enzyme's structure is so closely correlated to its function that even a slight change in a protein's primary structure can affect its conformation and ability to function. For example, although noncompetitive inhibitors bind to the enzyme away from its active site, they alter the enzyme's conformation so that the active site no longer has the right structure to bind with the substrates, preventing it from functioning correctly.
Chemical structure of hemoerythrin?
Active site of hemerythrin before and after oxygenation. Single oxygenated hemerythrin protein.
Why do enzymes have an active site?
The structure of an enzymes and its active site determine which substrates will work for the enzyme. This is called the lock and key method. The active site is the lock and the substrate is the key.
How is Protein Structure related to its function?
The structure of its active site relates to its function, since they have a certain degree of especificity towards substrates.
Does the shape of an enzyme protein determine specificity?
Shape of an enzyme specifically shape of its active site determines enzyme specificity .
How is protein structure involved in enzyme specificity?
The R groups of the amino acids in its active site
What is the relationship between the function and structure of a protein?
Proteins are composed of amino acids, each of which have their own special properties. The non-polar amino acids would fold into the interior of the protein during protein folding, because they are hydrophobic. A protein consists of a primary structure, which consists of the amino acid chain. The secondary structure is how the amino acids join together into alpha helices and beta pleated chains and form hydrogen bonds. The tertiary structure is when disulphide bridges form, which maintain the protein's 3D shape, and the 3D shape begins to emerge. The quaternary structure is an assortment of several polypeptides, and constitutes the entire protein. The final shape of the protein determines its function.For example an enzyme carry out catalytic functions are mainly accomplished by it's catalytic core residues(place where substrate binds). when the 3D structure of protein is properly made(folded) then it is active, when a single residue is mutated or any improper folding leads to the enzyme either hyperactive, poorly active or inactive.
Why is protein conformation important?
A protein's shape is very important for its function. For example, enzymes react with substrates at an active site. This is very specific and if the shape changes, it will not react at efficiently (or at all).
Is an enzyme a structural protein or functional protein?
Yes, enzymes are proteins and it is their sequence of amino acids (primary structure) that determines what kind of an enzyme it is and makes all the enzymes unique and it is the tertiary structure of enzymes that maintains their shape and give rise to the unique active site. When an enzyme is denatured, it loses its tertiary structure and therefore its shape.
Biological membranes are primarily composed of?
Lipids. Naturally there are many different types.
How an inactive protein can be converted into active protein?
An inactive protein can be converted into an active protein through the process of proteolysis. This process happens through the hydrolysis of the peptide bond, which is aided by cellular enzymes.
