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No single mutation is responsible for this disease. It just happens by abnormality in the red blood cells. It affects the hemoglobin.
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∙ 14y ago
Wiki User
∙ 13y agosubstitution causes sicle cell anemia
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Define a genetic mutation and state the types of genetic mutations?
Point mutation: single nucleotide is replaced with another. ex: sickle cell anemia.
Is anemia a genetic disorder?
Anemia is a broad disorder that literally translates as 'no blood'. In medical practice, anemia is a condition in which there are insufficient normal red blood cells to provide oxygen to the body tissues. Anemia can be caused by a wide variety of things: large volume blood loss, infection, cancer and toxins can all result in various types of anemia. There are also genetic causes of anemia. Two commonly discussed genetic anemias are sickle cell anemia and hemophilia-related anemia. Sickle cell anemia developed in Africa, where malaria parasites are common. A heterozygous individual has about 15% abnormal red blood cells that are crescent-shaped and don't transport oxygen well. Hemophilia was traced to a point mutation in the English royal line in the Middle Ages, which then spread throughout Europe via marriage among the royal houses. Hemophilia actually results in blood that does not clot properly, which can result in anemia due to chronic blood loss through hemorrhages.
The blood disorder characterized by anemia?
many conditions. few include thalassemia, acute blood loss, sickle cell anemia, vitamin B12 or folic acid or iron deficiency, post infection anemia, hereditary spherocytosis.
What if the cellular process that carries out hereditary instructions would be affected by a mutation?
Depending on the type of mutation, this could be harmless, or it could be harmful and even lethal.For example, a point mutation changes one base in a codon. Since most amino acids have more than one codon, this mutation may still code for the same amino acid. For example, both TTT and TTC codons code for the amino acid phenylalanine, so if TTT was mutated to TTC, the mutation would have no effect.However, in sickle cell anemia, a life-threatening genetic disorder, is also caused by a point mutation, in which the codon CTC is mutated to CAC. The codon CTC codes for the amino acid glutamine, and CAC codes for the amino acid valine. This change in just one codon causes the hemoglobin molecule to have an altered structure, which causes the red blood cells carrying the mutated hemoglobin molecule to be stiff and have a concave (sickle) shape. The sickle-shaped cells clog blood vessels and do not transport oxygen effectively, which causes pain and damage to the organs, shortening the lifespan by about 30 years. A person must inherit the mutated gene from both parents in order to be affected.Source: http://learn.genetics.utah.edu/content/disorders/singlegene/sicklecell/There are other types of mutations, such as frameshift mutations, and chromosomal mutations that can negatively impact the affected organism.
Is point mutation lethal?
No. Point mutations, or those resulting from a change in one or a few nucleotides at a single location in a DNA sequence. There are two types of point mutations: base substitutions and frameshift mutations. Not all mutations are in these coding sequences but if they are, then the result can be different or non-functioning proteins. They are considered to be neutral, beneficial or harmful. Two harmful point mutations are sickle cell anemia and polycystic kidney disease.
Define a genetic mutation and state the types of genetic mutations?
Point mutation: single nucleotide is replaced with another. ex: sickle cell anemia.
What kinds of anemia are there?
The different types of Anemia include: . Iron Deficiency Anemia - Is causes by blood loss, or lack of iron in the diet. . Pernicious Anemia - It occurs when the body is unable to absort Vitiman B12 . Folic Acid Deficiency Anemia - It occurs when there is a lack of folic acid in the diet. . Hemolytic Anemia - It is an inherited or acquired type of anemia that causes the red blood cells to be deformed, so the body breaks down the red blood cells too fast. . Sickle Cell Anemia - Inherited disease that occurs when the red blood cells are sickle shaped. The hemoglobin doesn't work right, the shape of the red blood cells causes them to clog the blood vessels and break down easily.
What are types of anaemia?
there are over 400 types of anemia. such as sickle cell, G6PD anemia, iron deficiency, B12 deficiency, aplastic, megaloblasic/pernicious, hemolytic, hemoglobin, Thalassemia, Excessive destructions of red blood cells and many more. 3 major types of anemias: low RBC anemias Low hemoglobin content abnormal hemoglobin
Is anemia a genetic disorder?
Anemia is a broad disorder that literally translates as 'no blood'. In medical practice, anemia is a condition in which there are insufficient normal red blood cells to provide oxygen to the body tissues. Anemia can be caused by a wide variety of things: large volume blood loss, infection, cancer and toxins can all result in various types of anemia. There are also genetic causes of anemia. Two commonly discussed genetic anemias are sickle cell anemia and hemophilia-related anemia. Sickle cell anemia developed in Africa, where malaria parasites are common. A heterozygous individual has about 15% abnormal red blood cells that are crescent-shaped and don't transport oxygen well. Hemophilia was traced to a point mutation in the English royal line in the Middle Ages, which then spread throughout Europe via marriage among the royal houses. Hemophilia actually results in blood that does not clot properly, which can result in anemia due to chronic blood loss through hemorrhages.
How does one avoid getting aenima?
Iron deficiency anemia can be avoided by eating a sufficient amount of iron. Sources of iron include meats and spinach. Other types of anemia, such as sickle cell anemia and pernicious anemia is a result of disease processes and genetics and are not preventable.
What are two types of blood diseases?
Diseases that affect your blood include:AnemiaAnemia, AplasticAnemia, FanconiAnemia, HemolyticAnemia, Iron-DeficiencyAnemia, PerniciousAnemia, Sickle CellAntiphospholipid Antibody SyndromeDeep Vein Thrombosis (DVT, Thrombophlebitis)Disseminated Intravascular Coagulation (DIC)Excessive Blood ClottingHemochromatosisHemophiliaImmune Thrombocytopenic Purpura (ITP)LeukemiaLymphocytopeniaPolycythemia VeraPulmonary EmbolismRh IncompatibilityThalassemiasThrombocytopeniaThrombocythemia and ThrombocytosisThrombophlebitis (Deep Vein Thrombosis, DVT)Thrombotic Thrombocytopenic Purpura (TTP)Von Willebrand Disease
The blood disorder characterized by anemia?
many conditions. few include thalassemia, acute blood loss, sickle cell anemia, vitamin B12 or folic acid or iron deficiency, post infection anemia, hereditary spherocytosis.
What are all the types of anemia in livestock?
There are 3 types of Livestock anemia. Infectious anemia, Nutrition anemia, and bovine anemia. Bovine anemia is found mostly in cows.
How many types of anemia are here?
There are several types of anemia. The term means without blood. It could be caused by excessive bleeding or damage to the bone marrow. Anemia is one of the most common disorders of the blood. It can be due to excessive blood loss or hemorrhage. Or deficient red blood cell production. Anemia can be classified in several ways: macrocytic anemia, normocytic anemia, microcytic anemia. Some of the more familiar ones are: pernicious anemia due to lack or low B12, iron deficiency anemia due to lack of iron, thalassemia, lead toxicity anemia, hypothyroidism, aplastic anemia, sickle cell anemia, Rh disease, and renal infection among others.
What if the cellular process that carries out hereditary instructions would be affected by a mutation?
Depending on the type of mutation, this could be harmless, or it could be harmful and even lethal.For example, a point mutation changes one base in a codon. Since most amino acids have more than one codon, this mutation may still code for the same amino acid. For example, both TTT and TTC codons code for the amino acid phenylalanine, so if TTT was mutated to TTC, the mutation would have no effect.However, in sickle cell anemia, a life-threatening genetic disorder, is also caused by a point mutation, in which the codon CTC is mutated to CAC. The codon CTC codes for the amino acid glutamine, and CAC codes for the amino acid valine. This change in just one codon causes the hemoglobin molecule to have an altered structure, which causes the red blood cells carrying the mutated hemoglobin molecule to be stiff and have a concave (sickle) shape. The sickle-shaped cells clog blood vessels and do not transport oxygen effectively, which causes pain and damage to the organs, shortening the lifespan by about 30 years. A person must inherit the mutated gene from both parents in order to be affected.Source: http://learn.genetics.utah.edu/content/disorders/singlegene/sicklecell/There are other types of mutations, such as frameshift mutations, and chromosomal mutations that can negatively impact the affected organism.
What are all the names of anemia are?
I only know of two types of anemia and i would like to know the rest for my school research project, name the ones that are not already said. there is the: Sickle cell, Iron Deficiency, please name 398 more, thank you so much!
Name 2 major types of mutation?
i] spontaneous mutation ii] induced mutation iii] germinal mutation iv] somatic mutation v] chromosomal mutation vi] gene mutation are the some of the major types of mutation......
