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Some have, notably the excellent Khadija, first wife (and only wife during her lifetime) of the Prophet Mohammed. He was her employee, and she proposed to him.
She plays with herself while talking to you
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Oprah Winfrey (APEX)
Margaret Floy Washburn.
Mary Surratt, the first woman executed by the federal government.
Mary McLeod Bethune was the first African American woman to head a federal agency
kim Campbell
Juliette Gordon Lowe
The cast of Used Books - 2007 includes: Danielle Bourgeois as Woman 1 Melissa Bowler as Store Employee 3 Frank Budelman as Book Buyer Jacqueline Middler as Woman 3 Mia Shaffer as Store Employee 2 Glenn Shea as Store Employee 1 Chuck Slavin as Man 1 Tim Thibodeau as Man 4 Darya Zabinski as Woman 2
Theodora is perhaps the most influential and powerful woman in the Roman Empire's history, which shows that women could hold political power.