They are created by web programmers. If you have idea for new internet app, the cheaper choice is to hire freelancer or some web design company.
Oxbridge Applications was created in 1999.
Net Applications was created in 1999.
Wholesale Applications Community was created in 2010.
Journal of Biomaterials Applications was created in 1986.
Scientific Computer Applications was created in 1969.
Space Applications Centre was created in 1972.
Microcomputer Applications Associates was created in 1972.
Postgraduate Applications Centre was created in 1998.
National Center for Supercomputing Applications was created in 1986.
Regional Economics Applications Laboratory was created in 1989.
National Center for Supercomputing Applications - Bulgaria - was created in 2008.
Applications of what? On Windows, for example, you can create Windows-applications in C.