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What is apc?
APC is classified as a tumor suppressor gene. Tumor suppressor genes prevent the uncontrolled growth of cells that may result in cancerous tumors. The protein made by the APC gene plays a critical role in several cellular processes that determine whether a cell may develop into a tumor.
Who identified the p53 gene?
The p53 gene was identified in 1979 by Arnold Levine, David Lane, and William Old. It wasn't until 1989 that the gene was found to be a tumor suppressor.
What is the difference between a tumor suppressor gene and an oncogene?
Oncogenes regulate cell division, so if it is placed near an overly active gene, it may itself become overly active, thus causing cancer. Tumor suppressors suppress tumors and will only cause cancer if it stops its activity, contrary to oncogenes.
What are two types of genes that when disrupted can cause cancer?
The two genes considered responsible for the cause of cancer are the oncogene and the tumor suppressor gene.
What are tumor suppressor and oncogenes genes?
Tumor suppressor genes are normal genes that carry out several functions: * slow down cell division * repair mistakes made when DNA is being replicated * tell cells when to die (a process known as apoptosis or programmed cell death) A mutation in a tumor suppressor gene allows cells to grow out of control, which can lead to cancer ie the growth of a tumor. About 30 tumor suppressor genes have been identified, including p53, BRCA1, BRCA2, APC, and RB1. A good analogy for tumor suppressor genes is the brake pedal on a car - it normally keeps the cell from dividing too quickly just as a brake keeps a car from going too fast. If the brakes on a car fail, the car goes out of control; similarly, when something goes wrong with the gene, such as a mutation, cell division can get out of control. See: http://www.cancer.org/docroot/ETO/content/ETO_1_4x_oncogenes_and_tumor_suppressor_genes.asp http://envirocancer.cornell.edu/FactSheet/Genetics/fs6.TSgenes.cfm http://www.cancerquest.org/index.cfm?page=52
What effect does oncogenes have on cells?
Cells with an oncogene become over-stimulated to divide more often than normal. The chances of cancer developing are increased if a mutation to a tumor-suppressor gene also occurs. As an oncogene is a cancer-causing gene
What is the P53 gene function?
p53 is a gene that codes for a protein (p53) that is an important tumor suppressor. Although the number of pathways and roles of p53 continue to expand it is, perhaps, most well known for slowing cell proliferation or inducing apoptosis if DNA damage or uncontrolled growth is detected.
What is the result of a mutation occurring in a suppressor gene?
loss of existing function
What is the p35 cancer gene?
tumor suppresser gene that could turn into an oncogene
What kind of brain tumor did Gene Siskel have?
glioma
If p53 is a tumor suppressor gene why can it not stop cancer?
It may be able to once more research and testing is done. It has been shown, however, that just supplementing or replacing the damaged P53 can not be effectively used yet to suppress tumors since that would cause premature aging.
What did Gene Siskel die of?
Complications after surgery to remove a brain tumor
