maybe Scottie Thompson?
Sorry. I made a mistake. It's not an aspca commercial. It's a Humane Society commercial with Wendie Malick. There are no words in the song playing. It is electric guitar (maybe synthesizer). It sounds like something that would be used in a horror movie.
"Walk" by Foo Fighters
Paul McCartney
Musicians have specific ways of playing as people have their specific ways of speaking. One can always recognize John Wayne when he speaks as well as people with a tuned musical ear can recognise Eddie Van Halen as he plays. I do not have proof, but I believe the band playing in the Radio commercial for the 2011 Jeep Grand Cherokee is a band called Godsmack.
Collective Soul - The World I Know
The cast of The Guitar Is Their Song - 2011 includes: Abel Garcia Lopez as Guitar Maker Jose Luis Diaz as Guitar Maker
Gary Teaches Guitar - 2011 was released on: USA: 11 July 2011 (internet)
Excused - 2011 Guitar Zero - 1.50 was released on: USA: 9 December 2011
Gary Teaches Guitar - 2011 1-1 was released on: USA: 11 July 2011
Gary Teaches Guitar - 2011 1-2 was released on: USA: 15 August 2011
Gary Teaches Guitar - 2011 1-3 was released on: USA: 23 September 2011