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They Are No Creeper Boss Boss In Minecraft.
Ozma is the hardest boss in the game
Ganondorf I'd say Bouldergeist from Super Mario Galaxy with Dare Devil comet. It is almost impossible to defeat him.
It matters what game you are playing. For example i play Wizard101 and so far the hardest boss to me is Jabberwock.
orcram
The hardest boss is Sigma
you
the dog
The Moon Lord
I'd say a lot of hard enemies are in Peach's Courtyard and inside Peach's Castle. The ones in Peach's Castle are harder though. The hardest enemy would be Dark Mechawful. (He's a blue robot looking guy and he's in Peach's Castle) Hope I helped!
The next hardest boss I'd say is Kolokotos.
What boss.