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Such an organism would never be able to survive in any environment, and any ball-like characteristics would be selected out.

The organism would also not exist because there is an upper limit on the size cells can be due to physical constraints. A 120 pound single-celled human would probably have a diameter of 2-3 feet, meaning its radius is going to be about 1.5 ft. It would take too long for oxygen molecules to traverse that distance in order to reach the middle of the cell. To overcome this issue, cells need to be extremely small.

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Q: Why are humans not just one big 120 lb cell?
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