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Why are sex-linked recessive disorders such as hemophilia are most often seen in mails and rarely seen n females?
Wiki User
∙ 9y ago
This is due to the fact that females have two X chromosomes while males have only one, lacking a 'back up' copy for the defective gene the defective gene becomes manifest more easily in males. Because females have two X chromosomes and because hemophilia is rare, the chance of a female having two defective copies of the gene is very low, thus females are almost exclusively asymptomatic carriers of the disorder. It is very rare for a female to have hemophilia
Wiki User
∙ 12y ago
Wiki User
∙ 14y agoThe recessive genes are present on the X-chromosome. Female chromosome has another X-chromosome, which is dominant and masks the defective gene, and it is quite rare that both the chromosomes have recessive alleles. But, in males, the Y-chromosome has nothing to over mask the defective gene and the abnormality shows up in the form of the disease.
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Why is hemophilia rarely expressed in females?
Because hemophilia is a disease linked to a recessive gene on the X-chromosome, females have another X-chromosome to block out the diseased one. However, males have only one X-chromosome, so they are more often subject to hemophilia.
Could two phenotypically normal parents have a child with Hemophilia A?
XhXh - with hemophilia XhXH- carrier of hemophilia
A recessive gene located on the X chromosome is the cause of hemophilia in affected individuals. Males are more likely to have hemophilia than females because?
Males only have one copy of the X chromosome
Can a genetic disease affect anybody?
Exceptions are always there e.g hemophilia and many bleeding disorders don't affect females.
Why are sex linked recessive disorders such as hemophilia most often seen in males and rarely seen in females?
The recessive genes are present on the X-chromosome. Female chromosome has another X-chromosome, which is dominant and masks the defective gene, and it is quite rare that both the chromosomes have recessive alleles. But, in males, the Y-chromosome has nothing to over mask the defective gene and the abnormality shows up in the form of the disease.
How many alleles for hemophilia do females have?
females have 2 alleles for hemophilia, (X^hX^H) and (X^hX^h) if H is the normal allele and h is the recessive allele for hemophilia
What type of trait is hemophilia?
recessive sex-linked, X chromosome disorders, haemophilia is more likely to occur in males than females.
Why is hemophilia rarely expressed in females?
Because hemophilia is a disease linked to a recessive gene on the X-chromosome, females have another X-chromosome to block out the diseased one. However, males have only one X-chromosome, so they are more often subject to hemophilia.
Is hemophilia recessive or dominant?
Hemophilia ia a sex linked disorder that is normally recessive. There are many cases however where trait shows "incomplete or shared" dominance. In these cases the females will have lowered percentages of the clotting factor proteins and may for all intents and purposes be considered mild or moderate hemophiliacs themselves.
Why can females but not males be carriers of sexlinked genetic disorders?
Several genetic disorders are caused by genes on the X chromosomes.
Could two phenotypically normal parents have a child with Hemophilia A?
XhXh - with hemophilia XhXH- carrier of hemophilia
A recessive gene located on the X chromosome is the cause of hemophilia in affected individuals. Males are more likely to have hemophilia than females because?
Males only have one copy of the X chromosome
Can a genetic disease affect anybody?
Exceptions are always there e.g hemophilia and many bleeding disorders don't affect females.
Why are sex linked recessive disorders such as hemophilia most often seen in males and rarely seen in females?
The recessive genes are present on the X-chromosome. Female chromosome has another X-chromosome, which is dominant and masks the defective gene, and it is quite rare that both the chromosomes have recessive alleles. But, in males, the Y-chromosome has nothing to over mask the defective gene and the abnormality shows up in the form of the disease.
Why is hemophilia more common in males than in females?
The genes associated with Hemophilia A and B are located on the X chromosome, which is one of the 2 sex chromosomes. For males, who have only 1 X chromosome, 1 altered copy of the gene in each cell is sufficient to cause hemophilia. In females, who have 2 X chromosomes, a mutation would have to occur in both copies of the gene to cause hemophilia. Since it is unlikely that females will have 2 altered copies of this gene it is therefor very rare for females to have hemophilia.
How come females don't suffer fomr hemophilia?
Females are much less likely to suffer from hemophilia because it is a recessive X linked genetic disorder. Women, having the chromosomal configuration of XX would need both X chromosomes to carry the marker for hemophilia because it is a recessive gene. Whereas men, with the chromosomal configuration of Xy do not have a "backup" X chromosome so if their only X chromosome has the hemophiliac trait, then that man will be a hemophiliac.
Is hemophilia a disorder?
The clinical answer would be yes, however there are many exceptions to the rule in the case of hemophilia. The trait for hemophilia is carried on the X chromosome and is often recessive. This being the case, since females have 2 X chromosomes, there is typically a dominant gene on their other X that corrects the disorder if one X carries the trait for hemophilia. Males, having only one X chromosome (paired with a Y chromosome) an only express the traits on the one X that they have. This being the case, a male with the trait for hemophilia on his X chromosome must be affected by it. In more recent years it has become understood that the trait for hemophilia is not as recessive as once thought. In many females the trait has shown incomplete or shared dominance with the otherwise normal gene. This often results in the female having low clotting factor levels and actually being considered a mild or moderate hemophiliac.
