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Why can a change in the amino acid sequence of a protein be damaging to its function?
Wiki User
∙ 11y ago
A molecule of DNA consists of 2 chains of nucleotides, coiled around each other to form the familiar double helix.
Each DNA nucleotide contains one of 4 bases: (A)denine, (G)uanine, (C)ytosine, (T)hymine. Each base is paired with it's complementary base on the opposite chain:
Adenine with Thymine (AT) and Guanine with Cytosine (GC).
Genetic words are a 3 base sequence that specifies a particular amino acid. There are 64 possible combinations of these 4 bases in the 3-base genetic words:
(4 x 4 x 4 x 4 = 64).
61 of these combinations are used to code the 20 amino acids.
The other 3 combinations are stop sequences, used in synthesis.
Wiki User
∙ 15y ago
Wiki User
∙ 15y agoDepends. There are three types of point mutations (changes affecting just one nucleic base pair):
Substitution - the wrong nucleic acid is present. Most of these are silent, but they can result in the wrong amino acid being coded for (Sickle Cell is one of these). In a worst case, they result in the stop codon being found in the middle of a sequence so the protein is truncated.
Deletion - one nucleic acid is removed. These are bad, and cause a frame-shift. The protein is most likely completely changed.
Insertion - an extra nucleic acid is inserted. Also a frame-shift, see above.
Other larger mutations can have similar effects.
Wiki User
∙ 9y agoProteins are complex molecules. Each type of protein has a unique three-dimensional shape determined by how the protein folds up. If it does not fold up into the correct shape, it cannot carry out its function in the cell. A protein is held in its shape by bonds formed between amino acids, which are spaced out along the protein molecule. If the wrong amino acid is present, the bond cannot be formed and so the protein cannot take up its correct shape and carry out its function. For example, the disease sickle cell anemia is caused by a single incorrect amino acid in the hemoglobin molecule - a mistake that can be fatal!
Wiki User
∙ 11y agoeither it doesn't change the protein or it changes the protein's shape
Wiki User
∙ 13y agoYes it would. It would change the sequence of the codon which will attach to another amino acid
Wiki User
∙ 11y agoAdd your answer:
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How does the sequence of DNA affect the function of a protein?
The sequence of nucleotides in DNA molecule is equivalent and is closely related to an amino acid sequence in the protein molecule. If for any reason the sequence of DNA nucleotides changes it will be reflected in amino acid sequence in the protein. Moreover, the correct sequence of amino acid in the protein will form the correct three-dimensional structure, or tertiary structure, that will confer the biological activity to protein. If a wrong amino acid is translated from a mutated gene in the DNA could change the spatial structure of the protein and therefore modify or erase its biological function.
When a nitrogenous base is inserted or delete how does that affect the amino acid sequence?
The amino acid sequence is shifted, and this kind of mutation is called a frame shift mutation. All of the amino acid sequence after the mutation will be changed, which will cause a change in shape of the protein, which will then probably result in a nonfunctional protein, since the shape of a protein determines its function.
What change in DNA base sequence that codes for a respitory protein will most likely cause?
a change in the sequence of amino acids. -P
What is a chromosomal mutation?
mutation is a permanent change in the DNA sequence of a gene and can alter the amino acid sequence of the protein encoded by the gene..
A change in the sequence of DNA that results in a protein that is too short?
Nonsense mutation
How is it possible for a point mutation to have no effect on the function of gene?
If the point mutation does not change the protein to be translated in the 3-letter sequence, then it will have no effect on the gene's function.
Why the addition of an extra base in a DNA sequence would change the message carried by a DNA molecule?
It could change the type of protein that would be produced hence change the structure and function of that protein.
How does the sequence of DNA affect the function of a protein?
The sequence of nucleotides in DNA molecule is equivalent and is closely related to an amino acid sequence in the protein molecule. If for any reason the sequence of DNA nucleotides changes it will be reflected in amino acid sequence in the protein. Moreover, the correct sequence of amino acid in the protein will form the correct three-dimensional structure, or tertiary structure, that will confer the biological activity to protein. If a wrong amino acid is translated from a mutated gene in the DNA could change the spatial structure of the protein and therefore modify or erase its biological function.
Explain why the addition of an extra base in a DNA sequence would change the message carried by a DNA molecule?
It could change the type of protein that would be produced hence change the structure and function of that protein.
When a nitrogenous base is inserted or delete how does that affect the amino acid sequence?
The amino acid sequence is shifted, and this kind of mutation is called a frame shift mutation. All of the amino acid sequence after the mutation will be changed, which will cause a change in shape of the protein, which will then probably result in a nonfunctional protein, since the shape of a protein determines its function.
How can a mutation in a base sequence cause a change in a protein?
dna in a cell needs protein and chromosomes.
What change in DNA base sequence that codes for a respitory protein will most likely cause?
a change in the sequence of amino acids. -P
How can a mutation in a DNA base sequence cause a change in protein?
dna in a cell needs protein and chromosomes.
Do mutations always alter the encoded protein structure and function?
No. Since a mutation in the DNA may not necessarily result in a change to the encoded amino acid in the protein sequence, it is entirely possible. Further, the protein function will likely not change when an amino acid is replaced with one of similar chemical properties. Sometimes it does, sometimes it doesn't. This is the field that molecular evolutionary biologists study.
How can a mutation in a DNA bases sequence cause a change in a protein?
dna in a cell needs protein and chromosomes.
How can a mutation in a DNA base sequence cause change in a protein?
dna in a cell needs protein and chromosomes.
How can a mutation in DNA base sequence cause a change in a protein?
dna in a cell needs protein and chromosomes.
