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Why do antidepressants take more time to show effect?

Updated: 8/18/2019
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13y ago

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Most antidepressants require about 4 weeks, at therapeutic dosage (not starting dosage) to exert significant clinical effect. Some individuals report feeling better after just 1-2 weeks, but the norm is more like 4-5 weeks.

Although pharmaceutical company marketing efforts seek to characterize some antidepressants as "faster acting", there is no evidence based medicine to support this kind of claim.

Antidepressants require time to "build up" to a therapeutic level within the bloodstream (or so it is theorized).

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