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Amyotrophic Lateral Sclerosis is a degenerative disease of the nerve cells (neurons) in the brain and spinal cord that control voluntary muscle movement. These voluntary muscle movements include the kind of physical movement that Stephen Hawking cant do.

Neurons send messages to muscles - the lack of them means these messages are not being sent. As more messages are lost, muscles begin to weaken, twitching begins to occur, and eventually the victim is unable to move their limbs or body.

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Q: Why do patients with amyotrophic lateral sclerosis have trouble with physical movement?
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