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Repeated applications of drugs/pesticides result in resistance by way of natural selection. In any given population of organisms individual genetics will vary with varying degree expressed in their genotype. These variations result in phenotypic expression. Certain phenotypes will be more or less resistant to particular drugs/pesticides. Survival of the fittest. This is particulary important with organisms which have a fast reproductive cycle like bacteria and insects. This selecting for fitter individuals results in a population developing resistance. The ones suseptible to drugs/pest will die off leaving resistant ones. Over repated exposure and generations new genotypes with new phenotypes evolve resulting in "super bugs".

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Q: Why do repeated applications of single drug or pesticide result in resistance among bacterial strains and species of insects?
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