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The vaccines that protect you for years are for pathogens that change very little year after year. On the other hand, the flu virus is constantly changing. The type of flu people had last year is different from the type of flu they will have this year. On the other hand, those of us who had H1N1 in 1975 when it first came around will not get it this year. We are immune. We have lifetime immunity to that particular flu. We are not immune to another variety of flu but will need another new vaccine.

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Q: Why do some vaccines protect you for years while others only protect you for a season?
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