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The smell of vinegar from an old bottle of aspirin is an indication that the active ingredient in aspirin, acetylsalicylic acid, has decomposed. One of the products of the decomposition of aspirin is acetic acid, which is the active ingredient in vinegar and what smells. You should definitely not consume drugs that are past the expiration date that have decomposed!

You may need to discard it because some meds can be toxic after a certain date, or after being exposed to sunlight, humidity, etc. As cheap as aspirin is these days, one should not hesitate to replace it if there are any questions at all about its freshness.

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9y ago
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15y ago

aspirin is acetylsalicylic acid vinegar is acetic acid when in contact with moisture aspirin hydrolyzes to form acetic acid

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12y ago

Hydrolysis

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Q: Why do you need to discard a bottle of aspirin that has developed a vinegar-like odor?
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