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At conception.
Down syndrome is something you are born with; it is not something that will suddenly "appear."
At age 30, for example, a woman has about a 1 in 900 chance of conceiving a child with Down Syndrome. Those odds increase to about 1 in 350 by age 35. By 40 the risk rises to about 1 in 100.It occurs by going through fermentation and supplies alcohol in the brain resulting in down syndrome.
The number is the same everywhere.
Down's syndrome is increased with advanced maternal age, which is defined as more than 35 years of age.
The most common symptoms of Down syndrome are, a short stature in the neck, weak muscles, a wide, short neck with excess fat and/or skin, a single crease along the palm of the child's hands pesrons hands.