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Tequila and wine (red wine in particular) are thought to contain a chemical that can make certain individuals feel quite ill (headaches, nausea, etc). Symptoms can occur after as little as one drink. Occasionally, even the odor can cause mild adverse effects. When a sensitive person gets drunk from one of these drinks, they often have an excruciating hangover. This is a very poorly understood phenomenon and no one knows for certain why it occurs.

If you want to know more information, look up Red Wine Headache (RWH).

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11y ago
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11y ago

Most alcohols, including liqueurs, contain ethanol, which has an immediate effect on blood vessels within the body.

Ethanol causes blood vessels to dilate (expand), which leads to the flushed feeling that first-time drinkers or "lightweight" drinkers experience. Headaches form when blood vessels in the brain have been dilated. Over-consumption of alcohol is also one of the causes of permanent migraines, if the blood vessels in your brain become permanently damaged by the dilution.

Ethanol also has a dehydrating effect by causing increased urine production (diuresis) which leads to headaches, dry mouth and lethargy. These also contribute towards the symptoms of a hangover.

There is also another substance in alcoholic drinks which contributes to headaches, called tyramine. Tyramine is an amino acid which is known to trigger migraines in some (but not all) people. Red wine contains most Tyramine.

Mixing alcohol and medication can cause headaches. Substances in alcohol will react with medication in your blood. The effects depend on the type of medication you have taken, but one of the common effects are headaches. Alcohol also has the ability to potentially cancel out most medications, including the contraceptive (Birth Control) pill.

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Q: Why does drinking liqueurs cause headaches?
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